At least six people were killed Wednesday afternoon after a passenger bus crashed into a tractor- trailer and a car in US state of Tennessee, according to knoxnews.com, a local news website. There are also multiple injuries, the report said. The bus was traveling on the eastbound on Interstate 40 when it \"traveled across the median and struck a tractor-trailer and passenger car that were traveling westbound,\" a Tennessee Department of Safety official was quoted as saying, adding that the tractor-trailer caught fire and the bus overturned after the crash. Both directions of Interstate 40 were shut down after the crash, the report said.