Tiny fish offers big hopes in genome research

Discovery unlocks insights into cancer and heart disease One of the world's most popular aquarium fishes on Wednesday joined the rat, the mouse, fruit fly and nematode worm in the roll call of creatures whose DNA has been sequenced to help fight disease among humans. A consortium of researchers unveiled the genome of the zebra fish in the British journal Nature, declaring it made a vital model for pinpointing faulty genes.
The tiny striped fish, Danio rerio in Latin, has 26,000 genes, 70 percent of which are shared with humans.
Eighty-four percent of genes known to be associated with human disease have a zebra fish counterpart.
The fish has a brief life cycle and in the embryonic stage is transparent, which makes it highly useful in the lab.
The zebra fish has already unlocked insights into cancer and heart disease and advanced knowledge of muscle and organ development, including genes implicated in muscular dystrophy.
"We can readily create variations in their genome that are relevant to human health and disease. This has allowed a greater understanding of gene function and the finding of new targets for drug treatments," said Leonard Zon of the Children's Hospital of Boston, Massachusetts.
"Several small molecules discovered using the zebra fish system have recently entered clinical trials," he said in a press release.
"The availability of the genome sequence, coupled with the rapid expansion of disease models and chemical screening ability, ensures that the zebra fish system has a major place in bio medicine."