scientists identify 2 zika proteins linked to microcephaly
Last Updated : GMT 17:34:35
Emiratesvoice, emirates voice
Emiratesvoice, emirates voice
Last Updated : GMT 17:34:35
Emiratesvoice, emirates voice

Scientists identify 2 Zika proteins linked to microcephaly

Emiratesvoice, emirates voice

Emiratesvoice, emirates voice Scientists identify 2 Zika proteins linked to microcephaly

Dr. examines a 2-month-old with suspected microcephaly in Brazi
Washington - XINHUA

Scientists have identified two Zika proteins that might be responsible for microcephaly, making a small step toward preventing Zika-infected mothers from birthing babies with abnormally small heads.

"Our study reported microcephaly-related Zika proteins for the first time, providing target for future research on prevention and treatment," corresponding co-author Zhen Zhao, assistant professor of the University of Southern California, told Xinhua.

"However, we still have a long way to go when it comes to clinical applications," Zhao said.

The Zika virus contains 10 proteins, but only two, known as NS4A and NS4B, may handicap fetal brain formation, according to the study published Thursday in the U.S. journal Cell Stem Cell.

The findings were based on an examination of three strains of Zika in second trimester human fetal neural stem cells.

The researchers found the miscreant Zika proteins smack a cellular signaling gatekeeper called "Akt-mTOR pathway" until it is disoriented and can no longer properly guard brain development and autophagy regulation, the cell's recycling factories.

Autophagy usually digests and kills pathogens, however, when a family of viruses called flaviviruses, including Zika, dengue and hepatitis C, infects a cell, autophagy helps the virus proliferate.

"Zika loves and needs autophagy," senior corresponding author Jae Jung, professor of the University of Southern California, said in a statement.

"Zika raises the activity in this recycling factory so they can use the energy and nutrients there to replicate. It's possible that since Zika is using most of the energy, the neuronal stem cells are left with metabolic deficits. Thus the chances for them to differentiate and mature into neurons and other brain cell types is much lower."

When these two key proteins hijacked fetal neural stem cells, the size of brain "organoids" -- artificially grown balls of brain tissue in lab -- were on average halved, according to the study.

The researchers are also working on experiments to better demonstrate the functions of NS4A and NS4B in mouse models.

"It is important to remember that not every pregnant woman infected with Zika virus gives birth to a baby with microcephaly," Zhao said. "Nevertheless, we are trying to develop a cure for that percentage that does get Zika-related microcephaly."


Source : XINHUA

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

scientists identify 2 zika proteins linked to microcephaly scientists identify 2 zika proteins linked to microcephaly

 



Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

scientists identify 2 zika proteins linked to microcephaly scientists identify 2 zika proteins linked to microcephaly

 



Emiratesvoice, emirates voice Skincare PR Performance Full Year 2017

GMT 08:36 2018 Monday ,22 January

Skincare PR Performance Full Year 2017
Emiratesvoice, emirates voice New hunt for flight MH370 gets under way

GMT 10:28 2018 Wednesday ,24 January

New hunt for flight MH370 gets under way
Emiratesvoice, emirates voice Modern colorful bedroom renovation

GMT 12:12 2017 Thursday ,21 December

Modern colorful bedroom renovation
Emiratesvoice, emirates voice Five Saudi women pilots granted GACA licences

GMT 15:04 2018 Thursday ,30 August

Five Saudi women pilots granted GACA licences
Emiratesvoice, emirates voice Turkey detains dozens more

GMT 10:11 2018 Wednesday ,24 January

Turkey detains dozens more

GMT 17:01 2018 Thursday ,30 August

Television reporter killed in Mexico

GMT 10:08 2018 Wednesday ,24 January

Microsoft to open 4 data centres

GMT 05:36 2018 Monday ,15 January

Palestinians exhume body of disabled Gazan killed

GMT 13:01 2017 Thursday ,21 September

Global trade 'rebounds strongly' in first half

GMT 00:12 2017 Friday ,19 May

Sheikha Fatima chosen as 'Person of the Year'

GMT 09:12 2017 Tuesday ,01 August

Maia Diab is keen to present different works

GMT 08:22 2017 Wednesday ,14 June

Khalifa gets Ugandan President's letter

GMT 13:50 2011 Wednesday ,08 June

On the perfect moonwalk

GMT 09:33 2015 Thursday ,24 September

Julio Iglesias announced on birthday

GMT 07:51 2018 Monday ,22 January

'The Shape of Water' wins PGA best film

GMT 07:37 2018 Monday ,15 January

Japan sewers clean up their act
 
 Emirates Voice Facebook,emirates voice facebook  Emirates Voice Twitter,emirates voice twitter Emirates Voice Rss,emirates voice rss  Emirates Voice Youtube,emirates voice youtube  Emirates Voice Youtube,emirates voice youtube
emiratesvoieen emiratesvoiceen emiratesvoiceen emiratesvoiceen
emiratesvoice emiratesvoice emiratesvoice
emiratesvoice
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
emiratesvoice, Emiratesvoice, Emiratesvoice